Well it applies here, just not a lot of civilization at the end of the rivers in a lot of cases, just a place to land if all goes well....
When flyiing, you can get caught in some bad weather and have everything close in on you before you can get out of it. Sometimes if you see a ridge, you know that "Most" have a creek bed running down the valley so if you follow the ridge, and you can drop down to see it. That is only as a last ditch effort, in my experiance, "most ridges" have way too much "Cumlious Granite" (rocks in the clouds) lining them that needs to be avoided at all costs, and they are directly in your flight path in direct proportion to how badly you need to get out of the weather....
North of the Alaska Range, where Denali National Park is at, and all the rivers South of the Brooks Range, flow into the Yukon and most of the towns (of a few hundred people at best) along there, you will miss if you blink too long...