Another vote for H&R Block Tax Cut (Now in 2010 named H&R Block At Home).
TurboTax may be as good for the typical family return with maybe small rental or farm income to report.
Both can download your 1099's and investment statements from Schwab, Vanguard, etc, and also bring forward your last year's name/address/employer/deductions etc data. Accumulating all that data, with absolute precision, is half of the tax preparation project right there.
I switched from TT to TaxCut the year I inherited responsiblity to manage and eventually liquidate Dad's Trust. TaxCut had far better tools than TT for working with this complex and unfamiliar stuff. I completed the Estate Tax return (back before the exemption was raised) and a couple of years returns for the Trust itself before I got the assets retitled to the heirs. Plus of course preparing returns each year for self (Wages, Pensions, Rental, Farm, Itemized Deductions), 2 semi-adult kids, elderly Mom, and for Dad's final living year.
I reviewed all the Trust's bookkeeping and tax returns with a high priced, best-in-town CPA/tax attorney before I released the Trust assets and he said I nailed it, no corrections.
Good enough! I've used TaxCut ever since, and recommend it.