I've not had any issues yet. I had to transfer my email from Outlook Express to Microsoft Mail and the "transfer wizard" couldn't find the default folder for Outlook Express, but I was able to manually point to that folder and all was well. Other than that obvious program flaw, I really like Vista. It runs much faster on my system and has not crashed once yet. I was forced to reboot every day or so with XP or it would develop all sorts of odd glitches. Vista doesn't seem to suffer from those problems either.
Last night I saw Apple's new commercial with the two guys where Apple is taking shots at Vista. For the first time I have to say that I think Apple quit touting the benefits of their OS and are grasping at straws. Their commercial tries to get the viewer to believe that a user of MS Vista is constantly hounded by the security portion of the program. Plain and simple, that Apple commercial is misleading and I just lost a lot of respect for them. I have my security set at nearly the highest setting and I have no such problems they try to portray in the Apple commercial. As I made quite clear, I have been seriously considering buying a Mac. After seeing the apparent desperation and obvious attempt to mislead in their latest ad, I'm completely turned off by Apple and now think that MS may finally have an OS that has them worried. Otherwise, why lie and try to mislead the public rather than have the common "cute" commercials that point out certain benefits that the Mac had over Windows. So, after running Vista for a couple of weeks now, Apple blew it with me with their misleading attack ad. I no longer have any desire to purchase a Mac. And, that's from someone who was extremely open minded and very likely would have purchased one. From Apple's reaction, they apparently no longer have any advantage over Windows, now that Vista is out, and have resorted to misdirection to try to sell their system.
I've had no driver issue at all yet. The only conflict was that my 2005 version of Norton AntiVirus was not compatible. Honestly, I'm not that impressed with Norton anyway. I'm currently using the 90 day free trial period of MS "Care One". It seems to work fine.